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FlyGym Platform

Brain function emerges from whole-system interaction over time. FlyGym captures that complexity earlier, reducing animal use and accelerating candidate selection before the clinic.

What is FlyGym?

De-risk your compound before the clinic, in weeks.

FlyGym integrates automation, artificial intelligence, and neuroscience to uncover the causal link between adaptive behavioral changes and their origin in neuromuscular pathways, the root driver of behavior. It converts complex behavior into measurable biology, enabling the identification of precise interventions at the source of functional decline.

FlyGym goes beyond behavioral descriptions to identify the mechanistic sources of decline.

Screening

Early Toxicity Detection

Catch adverse effects in a whole-organism model before committing to costly vertebrate studies.

Efficacy Screening

Rapidly identify whether your compound delivers meaningful functional improvement across mobility, lifespan, and grip strength endpoints.

Off-Target Profiling

Detect unintended effects across multiple biological systems in a single platform, reducing downstream surprises.

Model & Output

Humanized Drosophila in vivo

By introducing human gene mutations into the fly genome, we build precise models of human diseases of interest to test new interventions.

Candidate Prioritization

Accelerate go/no-go decisions and evaluate the therapeutic potential of your intervention on brain health, in weeks not years.

FlyGym at a glance

FlyGym at a glance

What FlyGym Measures

FlyGym simultaneously quantifies motor performance across key biological dimensions directly relevant to human healthy aging.

Toxicity & Lifespan

Rapid identification of toxic compounds and lifespan effects at scale. Screen thousands of compounds for safety and longevity impact before advancing to costly vertebrate studies, dramatically reducing R&D risk and timeline.

Computer vision detection of fly death in lifespan assays

Mobility

Automated locomotion tracking and neuromuscular function quantification. Gait, speed, endurance, and grip strength decline are the most predictive biomarkers of aging, measured simultaneously across large fly populations.

Locomotion tracking: mobility performance

Motor Neuron Degeneration

Motor neuron degeneration with aging and disease is one of the most evolutionarily conserved biological phenomena. FlyGym enables longitudinal visualization, quantification, and analysis of motor neuron structural changes under compound intervention.

YOUNG

Fluorescence imaging of motor neuron morphology over time

Communication

Motor neurons signal muscles via neurotransmitters to enable rapid, on-demand actions such as running or climbing. FlyGym quantifies motor system structure–function coupling by measuring neuromuscular transmission longitudinally during aging under compound intervention.

Live patch-clamp recording at the neuromuscular junction

Muscle Activity

FlyGym measures real-time muscle activity to link motor neuron function to mobility, enabling causal mapping of compound effects across the motor system and behavioral output.

YOUNG
OLD

Real-time electromyography during locomotion

Kinematics

Unlock high-resolution behavioral insights with our fly-on-the-ball phenotyping platform. By combining precise locomotor assays with state-of-the-art 3D motion reconstruction, we capture subtle compound-induced effects that traditional assays often miss. Our platform quantifies detailed locomotor parameters such as leg coordination, and inertial dynamics, enabling sensitive and mechanistic evaluation of compound effects.

3D motion reconstruction and kinematic analysis

Additional Features

Sleep
Circadian Rhythm
Grip Strength
Associative Learning
Neurotransmitter Release
Neurodegeneration

Why Drosophila?

Human-Relevant Biology

Along with conserved structural and functional features of NMJs, about 75% of genes involved in human neurodegeneration and aging pathways have homologs in fruit flies.

Results in Weeks, Not Years

A 50-day lifespan enables affordable long term aging studies while capturing whole organism brain function and tissue interactions that cell culture models cannot replicate.

Behavioral Complexity That Counts

Aggression, mating, drunkenness, memory, sociability, sleep, circadian rhythms, neurodegenerative diseases, and many more.

The numbers behind the platform

14
Nobel Prizes
A century of validated science behind every assay we run
100K+
Publications
The established baseline your data builds on
3
Peer-reviewed validations
Platform credibility you can cite in your own filings

Test Your Compound With FlyGym

We de-risk target identification and demonstrate compound impact on brain health in weeks. Here's how a partnership works.

01

Submit your compound

Share your compound and research context. We assess feasibility and design the optimal assay panel for your target area.

02

FlyGym screens

Your compound is tested across our full behavioral assay panel: mobility, lifespan, grip strength, and humanized disease models.

03

Receive a full data report

Within 60 days, you receive a complete analysis package with statistical results, visualizations, and scientific interpretation.

What partners receive

  • Full behavioral dataset across all measured endpoints (mobility, lifespan, grip strength)
  • PDF summary report with statistical analysis and compound comparison
  • Call with the Juvion science team to review findings and discuss next steps
  • Sample report: Download a personalized example report ↗
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