Brain function emerges from whole-system interaction over time. NeuroGym captures that complexity earlier, reducing animal use and accelerating candidate selection before the clinic.
Behavioral and neuronal readouts. De-risk your compound before the clinic, in weeks.
NeuroGym integrates automation, artificial intelligence, and neuroscience to uncover the causal link between adaptive behavioral changes and their origin in neuromuscular pathways, the root driver of behavior. It converts complex behavior into measurable biology, enabling the identification of precise interventions at the source of functional decline.
NeuroGym at a glance
NeuroGym simultaneously quantifies motor performance across key biological dimensions directly relevant to human healthy aging.
Rapid identification of toxic compounds and lifespan effects at scale. Screen thousands of compounds for safety and longevity impact before advancing to costly vertebrate studies, dramatically reducing R&D risk and timeline.
Computer vision detection of fly death in lifespan assays
Automated locomotion tracking and neuromuscular function quantification. Gait, speed, endurance, and grip strength decline are the most predictive biomarkers of aging, measured simultaneously across large fly populations.
Locomotion tracking: mobility performance
Unlock high-resolution behavioral insights with our fly-on-the-ball phenotyping platform. By combining precise locomotor assays with state-of-the-art 3D motion reconstruction, we capture subtle compound-induced effects that traditional assays often miss. Our platform quantifies detailed locomotor parameters such as leg coordination, and inertial dynamics, enabling sensitive and mechanistic evaluation of compound effects.
3D motion reconstruction and kinematic analysis
Motor neuron degeneration with aging and disease is one of the most evolutionarily conserved biological phenomena. NeuroGym enables longitudinal visualization, quantification, and analysis of motor neuron structural changes under compound intervention.
Fluorescence imaging of motor neuron morphology over time
Motor neurons signal muscles via neurotransmitters to enable rapid, on-demand actions such as running or climbing. NeuroGym quantifies motor system structure–function coupling by measuring neuromuscular transmission longitudinally during aging under compound intervention.
Live patch-clamp recording at the neuromuscular junction
NeuroGym measures real-time muscle activity to link motor neuron function to mobility, enabling causal mapping of compound effects across the motor system and behavioral output.
Real-time electromyography during locomotion
Along with conserved structural and functional features of NMJs, about 75% of genes involved in human neurodegeneration and aging pathways have homologs in fruit flies.
A 50-day lifespan enables affordable long term aging studies while capturing whole organism brain function and tissue interactions that cell culture models cannot replicate.
Aggression, mating, drunkenness, memory, sociability, sleep, circadian rhythms, neurodegenerative diseases, and many more.
NeuroGym, our Drosophila-based discovery platform, is NAM-aligned: it screens for neuromuscular efficacy without mammalian testing, in step with the 3Rs and the regulatory move toward New Approach Methodologies.
We partner with brands to bring NeuroGym-validated, plant-derived ingredients into their healthy aging products. Here's how a partnership works.
Tell us about your compound and area of interest. We'll reach out to schedule a call with our science team.
